Tom Brown Group

Structure and Dynamics of Triazole-Linked DNA: Biocompatibility Explained

A. Dallmann, A. H. El-Sagheer, L. Dehmel, C. Muegge, C. Griesinger, N. P. Ernsting and T. Brown. Chem. Eur. J. 17 (52), 14714-14717, 2011.

2'-Aminoethoxy-2-amino-3-methylpyridine in Triplex-Forming Oligonucleotides: High Affinity, Selectivity and Resistance to Enzymatic Degradation

C. Lou, M. Shelbourne, K. R. Fox and T. Brown. Chem. Eur. J. 17 (52), 14851-14856, 2011.

Efficient reverse click labeling of azide oligonucleotides with multiple alkynyl Cy-Dyes applied to the synthesis of HyBeacon probes for genetic analysis

M. Gerowska, L. M. Hall, J. A. Richardson, M. Shelbourne and T. Brown. Tetrahedron 68 (3), 857-864, 2012.

Membrane Protrusion Coarsening and Nanotubulation within Giant Unilamellar Vesicles

I. Wegrzyn, G. D. M. Jeffries, B. Nagel, M. Katterle, S. R. Gerrard, T. Brown, O. Orwar, and A. Jesorka. J. Am. Chem. Soc. 133 (45), 18046-18049, 2011.

PNA HyBeacons for analysis of human mutations related to statin-induced myopathy

N. Gale, P. Kocalka, C. Mardle and T. Brown. Artificial DNA: PNA & XNA 2 (3), 1-11, 2011.

Click Nucleic Acid Ligation

A. H. El-Sagheer and T. Brown. Nucleic Acid Therapeutics (formerly Oligonucleotides) 21, A6, 2011.

Efficient RNA synthesis by in vitro transcription of a triazole-modified DNA template

A. H. El-Sagheer and T. Brown. Chem. Commun. 47 (44), 12057-12058, 2011.

Self-Assembled DNA-Based Fluorescence Waveguide with Selectable Output

J. K. Hannestad, S. R. Gerrard, T. Brown and B. Albinsson. Small 7 (22), 3178-3185, 2011.

Nanofabrication yields. Hybridization and click-fixation of polycyclic DNA nanoassemblies.

E. P. Lundberg, C. Plesa, L. M. Wilhelmsson, P. Lincoln, T. Brown and B. Norden. ACS Nano 5 (9), 7565-7575, 2011.

Biocompatible artificial DNA linker that is read through by DNA polymerases and is functional in Escherichia coli

A. H. El-Sagheer, A. P. Sanzone, R. Gao, A. Tavassoli and T. Brown. Proc. Natl. Acad. Sci. U.S.A. 108 (28), 11338-11343, 2011.

Discrimination against the Cytosine Analog tC by Escherichia coli DNA Polymerase IV DinB

J. M. Walsh, I. Bouamaied, T. Brown, L. M. Wilhelmsson and P. J. Beuning. J. Mol. Biol. 409 (2), 89-100, 2011.

Fast Copper-Free Click DNA Ligation by the Ring Strain Promoted Alkyne-Azide Cycloaddition Reaction

M. Shelbourne, X. Chen, T. Brown and A. H. El-Sagheer. Chem. Commun. 47, 6257-6259, 2011.

2’-Substituted 2-Amino-3-Methylpyridine Ribonucleosides in Triplex-Forming Oligonucleotides: Triplex Stability is Determined by Chemical Environment

C. Lou, Q. Xiao, R. R. Tailor, N. Ben Gaied, N. Gale, M. E. Light, K. R. Fox and T. Brown. Med. Chem. Comm. 2, 550-558, 2011.

Hydroxylation of methylated CpG dinucleotides reverses stabilisation of DNA duplexes by cytosine 5-methylation

A. Thalhammer, A. S. Hansen, A. H. El-Sagheer, T. Brown and C. J. Schofield. Chem. Commun. 47, 5325-5327, 2011.

Formation of stable DNA triplexes

K. R. Fox and T. Brown. Biochem. Soc. Trans. 39 (2), 629-634, 2011.

Ultrasensitive fluorescence-based methods for nucleic acid detection: towards amplification-free genetic analysis

R. T. Ranasinghe and T. Brown. Chem. Commun. 47, 3717-3735, 2011.

Characterization of photophysical and base-mimicking properties of a novel fluorescent adenine analogue in DNA

A. Dierckx, P. Diner, A. H. El-Sagheer, J. D. Kumar, T. Brown, M. Grotli and L. M. Wilhelmsson. Nucleic Acids Res. 39 (10), 4513-4524, 2011.

Improved synthesis of 5-hydroxymethyl-2'-deoxycytidine phosphoramidite using a 2'-deoxyuridine to 2'-deoxycytidine conversion without temporary protecting groups

A. S. Hansen, A. Thalhammer, A. H. El-Sagheer, T. Brown and C. J. Schofield. Bioorg. Med. Chem. Lett. 21 (4), 1181-1184, 2011.

Gauging the Flexibility of Fluorescent Markers for the Interpretation of Fluorescence Resonance Energy Transfer

J. J. Rindermann, Y. Akhtman, J. A. Richardson, T. Brown and P. G. Lagoudakis. J. Am. Chem. Soc. 133 (2), 279-285, 2011.

Rapid chemical ligation of oligonucleotides by the Diels–Alder reaction

A. H. El-Sagheer, V. V. Cheong and T. Brown. Org. Biomol. Chem. 9 (1), 232-235, 2011.