Tom Brown Group - Nucleic Acids Research

Interdisciplinary Research

Our research is interdisciplinary, focusing on nucleic acid chemistry and its applications in other fields including DNA diagnostics, forensic science and nanotechnology.

Over 350 research papers and patents

Our publications have been cited more than 14000 times.

Commercialization

Our research has led to the foundation of three companies, as well as the development of several new technologies in collaboration with industrial partners.

Latest news

'Split-and-Click' sgRNA

In a paper published today in Nature Communications, we demonstrate a new approach to the chemical synthesis of libraries of sgRNAs for CRISPR applications. Using the method, standard or chemically modified CRISPR sgRNA libraries can be prepared in a single tube by click ligation of an invariant Cas9-binding 79-mer and a library of variable genome-targeting 20-mers. See our blog post for more information: https://chemistrycommunity.nature.com/users/251216-arun-shivalingam/posts/47615-split-and-click-sgrna.

Latest paper

Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications

C. Thorpe, S. Epple, B. Woods, A. H. El-Sagheer and T. Brown. Org. Biomol. Chem. 2019.

Site map

External links

Contact

Tom Brown

Professor of Nucleic Acid Chemistry

University of Oxford

E-mail: tom...@chem.ox.ac.uk

Address

Chemistry Research Laboratory
Mansfield Road
Oxford
OX1 3TA

Join the group!

We are always looking for enthusiastic, hard-working people. If you are interested, please contact us.

Copyright © 2010-19 Tom Brown Group