Our research is interdisciplinary, focusing on nucleic acid chemistry and its applications in other fields including DNA diagnostics, forensic science and nanotechnology.
Over 350 research papers and patents
Our publications have been cited more than 14000 times.
Our research has led to the foundation of three companies, as well as the development of several new technologies in collaboration with industrial partners.
In a paper published today in Nature Communications, we demonstrate a new approach to the chemical synthesis of libraries of sgRNAs for CRISPR applications. Using the method, standard or chemically modified CRISPR sgRNA libraries can be prepared in a single tube by click ligation of an invariant Cas9-binding 79-mer and a library of variable genome-targeting 20-mers. See our blog post for more information: https://chemistrycommunity.nature.com/users/251216-arun-shivalingam/posts/47615-split-and-click-sgrna.
Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications
2019.Org. Biomol. Chem.