Do C-H...O Hydrogen-Bonds Contribute to the Stability of Nucleic-Acid Base-Pairs?

G. A. Leonard, K. E. McAuley-Hecht, T. Brown and W. N. Hunter. Acta Crystallogr. Sect. D. Biol. Crystallogr. 51, 136-139, 1995.

Abstract

The possible formation of inter-base C-H.O hydrogen bonds in A.T, A.U and certain non-Watson-Crick base pairs is examined. A geometrical analysis in conjunction with implications for the thermodynamic stability of the base pairs suggests that C-H.O hydrogen bonds could form in nucleic acid base pairs. They may alleviate destabilizing interactions that would arise if an unsatisfied hydrogen-bond acceptor were present and mediate secondary hydrogen-bonding effects in these base pairs.

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