Nucleic acid structure
In the early part of my academic career I used state of the art NMR and X-ray
crystallography to study the properties of base pair mismatches in DNA and their
implications for DNA repair. This produced a series of publications, examples
of which are the elucidation of the structures of DNA duplexes containing G.T
(View paper)
and A.C
(View paper)
mispairs.