Dr Lucy Hall
Lucy undertook an MChem degree in Chemistry at Southampton University, which involved a 4th year project in the Brown group. This confirmed her interest in the area of nucleic acid studies and she began her PhD in October 2007. Lucy’s research is in the field of fluorescence, specifically on the development of new fluorescent monomers for incorporation into nucleic acids. Most recently, she has specialised in synthesising a variety of derivatives of Cy-dyes which are attached to DNA through rigid linkers. Applications for fluorescent oligonucleotides are being explored in detail, particularly their use in real-time PCR-based genetic analysis. HyBeacon probes, Taqman probes, Molecular Beacons and Scorpion primers are all being investigated. Lucy started a post-doc in the group in 2011.
Efficient reverse click labeling of azide oligonucleotides with multiple alkynyl Cy-Dyes applied to the synthesis of HyBeacon probes for genetic analysis
(3), 857-864, 2012.Tetrahedron 68
A highly fluorescent DNA toolkit: synthesis and properties of oligonucleotides containing new Cy3, Cy5 and Cy3B monomers
(14), 2012.Nucleic Acids Res. 40
Non-covalent Single Transcription Factor Encapsulation Inside a DNA Cage
(8), 2284-2288, 2013.Angew. Chem. Int. Ed. 52