Tom Brown Group

Kinetics of Diffusion-Controlled DNA Hybridization in Lipid Monolayer Films Determined by Single Molecule Fluorescence Spectroscopy

J. K. Hannestad, R. Brune, I. Czolkos, A. Jesorka, A. H. El-Sagheer, T. Brown, B. Albinsson and O. Orwar. ACS Nano 2012.

Self reporting RNA probes as an alternative to cleavable small molecule mass tags

J. Riley, T. Brown, N. Gale, J. Herniman and G. J. Langley. Analyst 2012.

A New Modular Approach to Nanoassembly: Stable and Addressable DNA Nanoconstructs via Orthogonal Click Chemistries

S. R. Gerrard, C. Hardiman, M. Shelbourne, I. Nandhakumar, B. Norden and T. Brown. ACS Nano 2012.

Tension induces a base-paired overstretched DNA conformation

N. Bosaeus, A. H. El-Sagheer, T. Brown, S. B. Smith, B. Akerman, C. Bustamante and B. Norden. Proc. Natl. Acad. Sci. U.S.A. 109 (38), 15179-15184, 2012.

Assessing the biocompatibility of click-linked DNA in Escherichia coli

A. P. Sanzone, A. H. El-Sagheer, T. Brown and A. Tavassoli. Nucleic Acids Res. 2012.

Triplex-Directed Covalent Cross-Linking of a DNA Nanostructure

D. A. Rusling, I. Nandhakumar, T. Brown and K. R. Fox. Chem. Commun. 48, 9592-9594, 2012.

Fast and efficient DNA crosslinking and multiple orthogonal labelling by copper-free click chemistry

M. Shelbourne, T. Brown Jr, A. H. El-Sagheer and T. Brown. Chem. Commun. 2012.

A Label-Free, Electrochemical SERS Based Assay for the Detection of DNA Hybridization and the Discrimination of Mutations

R. P. Johnson, J. A. Richardson, T. Brown and P. N. Bartlett. J. Am. Chem. Soc. 134 (34), 14099-14107, 2012.

A highly fluorescent DNA toolkit: synthesis and properties of oligonucleotides containing new Cy3, Cy5 and Cy3B monomers

L. M. Hall, M. Gerowska and T. Brown. Nucleic Acids Res. 40 (14), 2012.

Triplex-Directed Recognition of a DNA Nanostructure Assembled by Crossover Strand Exchange

D. A. Rusling, I. S. Nandhakumar, T. Brown and K. R. Fox. ACS Nano 6 (4), 3604-3613, 2012.

Click Nucleic Acid Ligation: Applications in Biology and Nanotechnology

A. H. El-Sagheer and T. Brown. Acc. Chem. Res. 45 (8), 1258-1267, 2012.

Quadracyclic Adenine: A Non-perturbing Fluorescent Adenine Analogue

A. Dierckx, F. Miannay, N. Ben Gaied, S. Preus, M. Bjorck, T. Brown and L. M. Wilhelmsson. Chem. Eur. J. 18 (19), 5987-5997, 2012.

Real-Time Surface-Enhanced Raman Spectroscopy Monitoring of Surface pH during Electrochemical Melting of Double-Stranded DNA

R. P. Johnson, J. A. Richardson, T. Brown and P. N. Bartlett. Langmuir 28 (12), 5464-5470, 2012.

Secondary binding sites for heavily modified triplex forming oligonucleotides

A. S. Cardew, T. Brown and K. R. Fox. Nucleic Acids Res. 40 (8), 3753-3762, 2012.

The Effect of Base-Pair Sequence on Electrochemically Driven Denaturation

R. P. Johnson, R. Gao, T. Brown and P. N. Bartlett. Bioelectrochemistry 85, 7-13, 2012.

Structure and Dynamics of Triazole-Linked DNA: Biocompatibility Explained

A. Dallmann, A. H. El-Sagheer, L. Dehmel, C. Muegge, C. Griesinger, N. P. Ernsting and T. Brown. Chem. Eur. J. 17 (52), 14714-14717, 2011.

2'-Aminoethoxy-2-amino-3-methylpyridine in Triplex-Forming Oligonucleotides: High Affinity, Selectivity and Resistance to Enzymatic Degradation

C. Lou, M. Shelbourne, K. R. Fox and T. Brown. Chem. Eur. J. 17 (52), 14851-14856, 2011.

Efficient reverse click labeling of azide oligonucleotides with multiple alkynyl Cy-Dyes applied to the synthesis of HyBeacon probes for genetic analysis

M. Gerowska, L. M. Hall, J. A. Richardson, M. Shelbourne and T. Brown. Tetrahedron 68 (3), 857-864, 2012.

Membrane Protrusion Coarsening and Nanotubulation within Giant Unilamellar Vesicles

I. Wegrzyn, G. D. M. Jeffries, B. Nagel, M. Katterle, S. R. Gerrard, T. Brown, O. Orwar, and A. Jesorka. J. Am. Chem. Soc. 133 (45), 18046-18049, 2011.

PNA HyBeacons for analysis of human mutations related to statin-induced myopathy

N. Gale, P. Kocalka, C. Mardle and T. Brown. Artificial DNA: PNA & XNA 2 (3), 1-11, 2011.